Contact, Membership, Mission, Officers
Allied Meetings
Searchable Membership Directory
Employment Listings
 
Cardene I.V.

 

BRAIN INJURY


Compiled by Monica S. Vavilala, M.D.
University of Washington, Seattle, WA

I. General

1. Albanese J, Arnaud S, Rey M, Thomachot L, Alliez B, Martin C: Ketamine decreases intracranial pressure and electroencephalographic activity in traumatic brain injury patients during propofol sedation. Anesthesiology 87:1328-34, 1997.

2. Aldrich EF, Eisenberg HM, Saydjari C, Luerssen TG, Foulkes MA, Jane JA, Marshall LF, Marmarou A, Young HF: Diffuse brain swelling in severely head-injured children. A report from the NIH Traumatic Coma Data Bank. J Neurosurg 76:450-4, 1992.

3. Alexander MP: Mild traumatic brain injury: pathophysiology, natural history, and clinical management. Neurology 45:1253-60, 1995.

4. Asgeirsson B, Grande PO, Nordstrom CH, Berntman L, Messeter K, Ryding E: Effects of hypotensive treatment with alpha 2-agonist and beta 1-antagonist on cerebral haemodynamics in severely head injured patients. Acta Anaesthesiol Scand 39:347-51, 1995.

5. Bedell EA, DeWitt DS, Prough DS: Fentanyl infusion preserves cerebral blood flow during decreased arterial blood pressure after traumatic brain injury in cats. J Neurotrauma 15:985-92, 1998.

6. Bedell EA, Prough DS: Should induced hypertension be beneficial after traumatic brain injury?. Anesth Analg 87:751-3, 1998.

7. Bedell E, Prough DS: Anesthetic management of traumatic brain injury. Anesthesiol Clin North America 20:417-39, 2002.

8. Bedell EA, DeWitt DS, Prough DS: Fentanyl infusion preserves cerebral blood flow during decreased arterial blood pressure after traumatic brain injury in cats. J Neurotrauma 15:985-92, 1998.

9. Bissonnette B, Vinchon M: Traumatic head injury in children: physiolopathology and clinical management 21:133-40, 2002.

10. Bombardier CH, Rimmele CT, Zintel H: The magnitude and correlates of alcohol and drug use before traumatic brain injury 83:1765-73, 2002.

11. Bouma GJ, Muizelaar JP: Evaluation of regional cerebral blood flow in acute head injury by stable xenon enchanced computerized tomography. Acta Neurochir 59:34-40, 1993.

12. Bouma GJ, Muizelaar JP: Cerebral blood flow in severe clinical head injury. New Horiz 3:384-94, 1995.

13. Bruder N, Lassegue D, Pelissier D, Graziani N, Francois G: Energy expenditure and withdrawal of sedation in severe head-injured patients. Crit Care Med 22:1114-18, 1994.

14. Bula WI, Loes DJ: Trauma to the cerebrovascular system. Neuroimaging Clin North Am 4:753-72, 1994.

15. Bulger EM, Nathens AB, Rivara FP, Moore M, MacKenzie EJ, Jurkovich GJ; The Brain Trauma Foundation: Crit Care Med 30:1870-6, 2002.

16. Bullock MR, Lyeth BG, Muizelaar JP: Current status of neuroprotection trials for traumatic brain injury: lessons from animal models and clinical studies. Neurosurgery 45:207-17; discussion 217-20, 1999.

17. Bullock R: Mannitol and other diuretics in severe neurotrauma. New Horiz 3:448-52, 1995.

18. Cantu RC: Athletic head injuries. Clin Sports Med 16:531-42, 1997.

*19. Chesnut RM: The management of severe traumatic brain injury. Emerg Med Clin North Am 15:581-604, 1997.

20. Chesnut RM: Medical management of severe head injury: present and future. New Horiz 3:581-93, 1995.

21. Chesnut RM, Gautille T, Blunt BA, Klauber MR, Marshall LF: Neurogenic hypotension in patients with severe head injuries. Trauma 44:958-63; discussion 963-4, 1998.

22. Chesnut RM, Marshall LF, Klauber MR, Blunt BA, Baldwin N, Eisenberg HM, Jane JA, Marmarou A, Foulkes MA: The role of secondary brain injury in determining outcome from severe head injury. J Trauma 34:216-22, 1993.

23. Chesnut RM, Marshall SB, Piek J, Blunt BA, Klauber MR, Marshall LF: Early and late systemic hypotension as a frequent and fundamental source of cerebral ischemia following severe brain injury in the traumatic coma data bank. Acta Neurochir 59:121-5, 1993.

24. Chesnut RM: Medical management of severe head injury. New Horiz 3:581-593, 1995.

25. Clark RS, Kochanek PM, Obrist WD, Wong HR, Billiar TR, Wisniewski SR, Marion DW: Cerebrospinal fluid and plasma nitrite and nitrate concentrations after head injury in humans. Crit Care Med 24:1243-51, 1996.

26. Clifton GL, Choi SC, Miller ER, Levin HS, Smith KR Jr, Muizelaar JP, Wagner FC Jr, Marion DW, Luerssen TG: Intercenter variance in clinical trials of head trauma-experience of the National Acute Brain Injury Study: Hypothermia: J Neurosurg 95:751-5, 2001.

27. Clifton GL, Miller ER, Choi SC, Levin HS, McCauley S, Smith KR Jr, Muizalaar JP, Marion DW, Luerssen TG: Hypothermia on admission in patients with severe brain injury. J Neurotrauma 19:293-301, 2002.

28. Clifton GL, Robertson CS, Grossman RG, Hodge S, Foltz R, Garza C: The metabolic response to severe head injury. J Neurosurg 60:687-96, 1984.

29. Coles JP, Minhas PS, Fryer TD, Smielewski P, Aigbirihio F, Donovan T, Downey SP, Williams G, Chatfield D, Matthews JC, Gupta AK, Carpenter TA, Clark JC, Pickard JD, Menon DK: Effect of hyperventilation on cerebral blood flow in traumatic head injury: clinical relevance and monitoring correlates. Crit Care Med 30:1950-9, 2002.

30. Cooper PR: Head Injury. Baltimore, Williams and Wilkins Co., 1993.

31. Coplin WM, O'Keefe GE, Grady MS, Grant GA, March KS, Winn HR, Lam AM: Thrombotic, infectious, and procedural complications of the jugular bulb catheter in the intensive care unit. Neurosurgery 41:101-7, 1997.

*32. Cormio M, Valadka AB, Robertson CS: Elevated jugular venous oxygen saturation after severe head injury. J Neurosurg 90:9-15, 1999.

33. Cortbus F, Jones PA, Miller JD, Piper IR, Tocher JL: Cause, distribution and significance of episodes of reduced cerebral perfusion pressure following head injury. Acta Neurochir 130:117-24, 1994.

34. Cruz J: Relationship between early patterns of cerebral extraction of oxygen and outcome from severe acute traumatic brain swelling: cerebral ischemia or cerebral viability? Crit Care Med 24:953-6, 1996.

35. Cruz J: Adverse effects of pentobarbital on cerebral venous oxygenation of comatose patients with acute traumatic brain swelling: relationship to outcome. J Neurosurg 85:758-61, 1996.

36. Cruz J: On-line monitoring of global cerebral hypoxia in acute brain injury: relationship to intracranial hypertension. J Neurosurg 79:228-33, 1993.

37. Cruz J, Jaggi JL, Hoffstad OJ: Cerebral blood flow, vascular resistance and oxygen metabolism in acute brain trauma: redefining the role of cerebral perfusion pressue? Crit Care Med 23:1412-17, 1995.

38. Czosnyka M, Kirkpatrick PJ, Pickard JD: Multimodal monitoring and assessment of cerebral haemodynamic reserve after severe head injury. Cerebrovasc Brain Metab Rev 8:273-95, 1996.

39. Czosnyka M, Matt BF, Smielewski P, Kirkpatrick PJ, Pickard JD: Cerebral perfusion pressure in head-injured patients: a noninvasive assessment using transcranial Doppler ultrasonography. J Neurosurg 88:802-8, 1998.

40. Czosnyka M, Smielewski P, Kirkpatrick P, Laing RJ, Menon D, Pickard JD: Continuous assessment of the cerebral vasomotor reactivity in head injury. Neurosurgery 41:11-17, 1997.

41. Dacey RG, Alves WM, Rimel RW, Winn HR, Jane JA: Neurosurgical complications after apparently minor head injury. J Neurosurg 65:203-10, 1986.

42. Davalos DB, Bennett TL: A review of the use of single-photon emission computerized tomography as a diagnostic tool in mild traumatic brain injury. Appl Neuropsychol 92-105, 2002.

43. Demellweek C, Baldwin T, Appleton R, Al-Kharusi A: A prospective study and review of pre-morbid characteristics in children with traumatic brain injury. Pediatr Rehabil 5:81-9, 2002.

44. DeWitt DS, Jenkins LW, Prough DS: Enhanced vulnerability to secondary ischemic insults after experimental traumatic brain injury. New Horiz 3:376-83, 1995.

*45. Dexter F: Research synthesis of controlled studies evaluating the effect of hypocapnia and airway protection on cerebral outcome. J Neurosurg Anesthesiol 9:217-22, 1997.

46. Diringer MN, Videen TO, Yundt K, Zazulia AR, Aiyagari V, Dacey RG Jr, Grubb RL, Powers WJ: Regional cerebrovascular and metabolic effects of hyperventilation after severe traumatic brain injury. J Neurosurg 96:103-8, 2002.

*47. Duhaime AC, Gennarelli TA, Thibault LE, Bruce DA, Margulies SS, Wiser R: The shaken baby syndrome. J Neurosurg 66:409-15, 1987.

48. Eisenberg HM, Gary HE Jr, Aldrich EF, Saydjari C, Turner B, Foulkes MA, Jane JA, Marmarou A, Marshall LF, Young HF: Initial CT findings in 753 patients with severe head injury. A report from the NIH Traumatic Coma Data Bank. J Neurosurg 73:688-98, 1990.

49. Faden AI: Pharmacological treatment of acute traumatic brain injury. JAMA 276:569-70, 1996.

50. Fahy BG, Sivaraman V: Current concepts in neurocritical care. Anesthesiol Clin North America 20:441-62, 2002.

51. Faillace WJ: Management of childhood Neurotrauma. Surg Clin North Am 82:349-63, 2002.

52. Fearnside M: Neuroprotective agents in severe head injury. Clin Exp Pharmacol Physiol 23:S54-5, 1996.

*53. Feldman Z, Robertson CS: Monitoring of cerebral hemodynamics with jugular bulb catheters. Crit Care Clin 13:51-77, 1997.

54. Feldman Z, Kanter MJ, Robertson CS, Contant CF, Hayes C, Sheinberg MA, Villareal CA, Narayan RK, Grossman RG: Effect of head elevation on intracranial pressure, cerebral perfusion pressure, and cerebral blood flow in head-injured patients. J Neurosurg 76:207-11, 1992.

55. Freshman SP, Battistella FD, Matteucci M, Wisner DH: Hypertonic saline (7.5%) versus mannitol: a comparison for treatment of acute head injuries. J Trauma 35:344-8, 1993.

*56. Gabriel EJ, Ghajar J, Jagoda A, Pons PT, Scalea T, Walters BC; Brain Trauma Foundation: Guidelines for prehospital management of traumatic brain injury. J Neurotrauma 111-74, 2002.

57. Gaskill-Shipley ME, Tomsick TA: Angiography in the evaluation of head and neck trauma. Neuroimaging Clin North Am 6:607-24, 1996.

58. Gean AD, Kates RS, Lee SH: Neuroimaging in head injury. New Horiz 3:549-61, 1995.

59. Ghajar J, Hariri RJ, Narayan RK, Iacono LA, Firlik K, Patterson RH: Survey of critical care management of comatose, head-injured patients in the United States. Crit Care Med 23:560-7, 1995.

60. Givner A, Gurney J, O'Connor D, Kassarjian A, Lamorte WW, Moulton S: Reimaging in pediatric neurotrauma: factors associated with progression of intracranial injury. J Pediatr Surg 37:381-5, 2002.

61. Gopinath SP, Cormio M, Ziegler J, Raty S, Valadka A, Robertson CS: Intraoperative jugular desaturation during surgery for traumatic intracranial hematomas. Anesth Analg 83:1014-21, 1996.

62. Gopinath SP, Robertson CS, Contant CF, Hayes C, Feldman Z, Narayan RK, Grossman RG: Jugular venous desaturation and outcome after head injury. J Neurol Neurosurg Psychiatry 57:717-23, 1994.

63. Gopinath SP, Robertson CS, Contant CF, Narayan RK, Grossman RG, Chance B: Early detection of delayed traumatic intracranial hematomas using near-infrared spectroscopy. J Neurosurg 83:438-44, 1995.

64. Gopinath SP, Valadka AB, Uzura M, Robertson CS: Comparison of jugular venous oxygen saturation and brain tissue Po2 as monitors of cerebral ischemia after head injury. Crit Care Med 27:2337-45, 1999.

65. Goren S, Kahveci N, Alkan T, Goren B, Korfali E: The effects of sevoflurane and isoflurane on intracranial pressure and cerebral perfusion pressure after diffuse brain injury in rats. J Neurosurg Anesthesiol 13:113-9, 2001.

66. Gower DJ, Lee KS, McWhorter JM: Role of subtemporal decompression in severe closed head injury. Neurosurgery 23:417-22, 1988.

67. Graham DI, Adams JH, Nicoll JA, Maxwell WL, Gennarelli TA: The nature, distribution and causes of traumatic brain injury. Brain Pathol 5:397-406, 1995.

68. Greene KA, Jacobowitz R, Marciano FF, Johnson BA, Spetzler RF, Harrington TR: Impact of traumatic subarachnoid hemorrhage on outcome in nonpenetrating head injury. Part II. Relationship to clinical course and outcome variables during acute hospitalization. J Trauma 41:964-71, 1996.

*69. Greenwald BM, Ghajar J, Notterman DA: Critial care of children with acute brain injury. Adv Pediatr 42:47-89, 1995.

70. Gurkin SA, Parikshak M, Kralovich KA, Horst HM, Agarwal V, Payne N: Indicators for tracheostomy in patients with traumatic brain injury. Am Surg 68:324-8, 2002.

71. Gurney JG, Rivara FP, Mueller BA, Newell DW, Copass MK, Jurkovich GJ: The effects of alcohol intoxication on the initial treatment and hospital course of patients with acute brain injury. J Trauma 33:709-13, 1992.

72. Hanley DF: Neurologic critical care and the management of severe head injury in the United States. Crit Care Med 23:434-5, 1995.

73. Harris CH, Smith RS, Helmer SD, Gorecki JP, Rody RB: Placement of intracranial pressure monitors by non-neurosurgeons 68:787-90, 2002.

74. Harris OA, Colford JM Jr, Good MC, Matz PG: The role of hypothermia in the management of severe brain injury: a meta-analysis. Arch Neurol 59:1077-83, 2002.

75. Hartung J, Cottrell JE: Statistics and hypothermia. J Neurosurg Anesthesiol 10:1-4, 1998.

76. Hartung J, Cottrell JE: Tirilazad and subarachnoid hemorrhage. J Neurosurg 92:508, 2000.

77. Heath K, Gupta A, Matta BF: Brain microprobe electrodes: a case for monitoring regional cerebral oxygenation in the severely head-injured patient. J Neurosurg Anesthesiol 10:22-4, 1998.

78. Holly LT, Kelly DF, Counelis GJ, Blinman T, McArthur DL, Cryer HG: Cervical spine trauma associated with moderate and severe head injury: incidence, risk factors, and injury characteristics. J Neurosurg 96:285-91, 2002.

79. Hsiang JK, Chesnut RM, Crisp CB, Klauber MR, Blunt BA, Marshall LF: Early, routine paralysis for intracranial pressure control in severe head injury: is it necessary? Crit Care Med 22:1471-6, 1994.

80. Hukkelhoven CW, Steyerberg EW, Farace E, Habbema JD, Marshall LF, Maas AI: Regional differences in patient characteristics, case management, and outcomes in traumatic brain injury: experience from the tirilazad trials. J Neurosurg 97:549-57, 2002.

81. Jaggi JL, Cruz J, Gennarelli TA: Estimated cerebral metabolic rate of oxygen in severely brain-injured patients: a valuable tool for clinical monitoring. Crit Care Med 23:66-70, 1995.

82. James CA: Magnetic resonance angiography in trauma. Clin Neurosci 4:137-45, 1997.

83. Jane JA, Anderson DK, Torner JC, Young W: Central Nervous System Trauma Status Report-1991. National Institute of Neurological and Communicative Disorders and Stroke, National Institute of Health 9:1-547, 1992.

84. Johnson DL, Duma C, Sivit C: The role of immediate operative intervention in severely head-injured children with a Glasgow Coma Scale score of 3. Neurosurgery 30:320-3, 1992.

*85. Junger EC, Newell DW, Grant GA, Avellino AM, Ghatan S, Douville CM, Lam AM, Aaslid R, Winn HR: Cerebral autoregulation following minor head injury. J Neurosurg 86:425-32, 1997.

86. Kakarieka A: Review on traumatic subarachnoid hemorrhage. Neurol Res 19:230-2, 1997.

87. Kawaguchi M, Sakamoto T, Ohnishi H, Karasawa J, Furuya H: Preoperative predictors of reduction in arterial blood pressure following dural opening during surgical evacuation of acute subdural hematoma. J Neurosurg Anesthesiol 8:117-22, 1996.

88. Kelly DF: Steroids in head injury. New Horiz 3:453-5, 1995.

89. Kelly DF, Kordestani RK, Martin MA, Nguyen T, Hovda DA, Bergsneider M, McArthur DL, Becker DP: Hyperemia following traumatic brain injury: relationship to intracranial hypertension and outcome. J Neurosurg 85:762-71, 1996.

90. Kelly DF, Martin NA, Kordestani R, Counelis G, Hovda DA, Bergsneider M, McBride DQ, Shalmon E, Herman D, Becker DP: Cerebral blood flow as a predictor of outcome following traumatic brain injury. J Neurosurg 86:633-41, 1997.

91. Kerr ME, Weber BB, Sereika SM, Darby J, Marion DW, Orndoff PA: Effect of endotracheal suctioning on cerebral oxygenation in traumatic brain-injured patients. Crit Care Med 27:2776-81, 1999.

92. Kontopoulos V, Foroglou N, Patsalas J, Magras J, Foroglou G, Yiannakou-Pephtoulidou M, Sofianos E, Anastassiou H, Tsaoussi G. Decompressive craniectomy for the management of patients with refractory hypertension: should it be reconsidered? Acta Neurochir 144:791-6, 2002.

93. Kordestani RK, Martin NA, McBride DQ: Cerebral hemodynamic disturbances following penetrating craniocerebral injury and their influence on outcome. Neurosurg Clin North Am 6:657-67, 1996.

94. Kordestani RK, Counelis GJ, McBride DQ, Martin NA: Cerebral arterial spasm after penetrating craniocerebral gunshot wounds: transcranial Doppler and cerebral blood flow findings. Neurosurgery 41:351-9, 1997.

95. Krieger MD, Levy ML, Apuzzo ML: Gunshot wounds to the head in an urban setting. Neurosurg Clin North Am 6:605-10, 1995.

96. Kumura E, Sato M, Fukuda A, Takemoto Y, Tanaka S, Kohama A: Coagulation disorders following acute head injury. Acta Neurochir 85:23-8, 1987.

97. Laffey JG, Kavanagh BP: Hypocapnia. N Engl J Med 347:43-53, 2002.

98. Lam JM, Hsiang JN, Poon WS: Monitoring of autoregulation using laser Doppler flowmetry in patients with head injury. J Neurosurg 86:438-45, 1997.

99. Lee JH, Martin NA, Alsina G, McArthur DL, Zaucha K, Hovda DA, Becker DP: Hemodynamically significant cerebral vasospasm and outcome after head injury: a prospective study. J Neurosurg 87:221-33, 1997.

100. Le Roux PD, Newell DW, Lam AM, Grady MS, Winn HR: Cerebral arteriovenous oxygen difference: a predictor of cerebral infarction and outcome in patients with severe head injury. J Neurosurg 87:1-8, 1997.

101. Levin HS, Saydjari C, Eisenberg HM, Foulkes M, Marshall LF, Ruff RM, Jane JA, Marmarou A: Vegetative state after closed-head injury. A Traumatic Coma Data Bank Report. Arch Neurol 48:580-5, 1991.

102. Levy DI, Rekate HL, Cherny WB, Manwaring K, Moss SD, Baldwin HZ: Controlled lumbar drainage in pediatric head injury. J Neurosurg 83:453-60, 1995.

103. Lewis SB, Myburgh JA, Thornton EL, Reilly PL: Cerebral oxygenation monitoring by near-infrared spectroscopy is not clinically useful in patients with severe closed-head injury: a comparison with jugular venous bulb oximetry. Crit Care Med 24:1334-8, 1996.

104. Lee MW, Deppe SA, Sipperly ME, Barrette RR, Thompson DR: The efficacy of barbiturate coma in the management of uncontrolled intracranial hypertension following neurosurgical trauma. J Neurotrauma 11:325-31, 1994.

105. Lo EH, Singhal AB, Torchilin VP, Abbott NJ: Drug delivery to damaged brain. Brain Res Brain Res Rev 38:140-8, 2001.

106. Lobato RD, Rivas JJ, Gomez PA, Castaneda M, Canizal JM, Sarabia R, Cabrera A, Munoz MJ: Head-injured patients who talk and deteriorate into coma. Analysis of 211 cases studied with computerized tomography. J Neurosurg 75:256-61, 1991.

107. Luchter S, Walz MC: Long-term consequences of head injury. J Neurotrauma 12:517-26, 1995.

*108. Mansfield RT: Head injuries in children and adults. Crit Care Clin 13:611-28, 1997.

109. Marion DW: Intracranial monitoring placement by midlevel practitioners. J Trauma 46:983-4, 1999.

110. Marion DW, Firlik A, McLaughlin MR: Hyperventilation therapy for severe traumatic brain injury. New Horiz 3:439-47, 1995.

*111. Marion DW, Penrod LE, Kelsey SE, Obrist WD, Kochanek PM, Palmer AM, Wisniewski SR, DeKosky ST: Treatment of traumatic brain injury with moderate hypothermia. N Engl J Med 336:540-6, 1997.

112. Marion DW, Spiegel TP: Changes in the management of severe traumatic brain injury: 1991-1997. Crit Care Med 28:16-8, 2000.

113. Marmarou A, Bandoh K, Yoshihara M, Tsuji O: Measurement of vascular reactivity in head injured patients. Acta Neurochir 58:18-21, 1993.

114. Marmarou A, Foda MA, Bandoh K, Yoshihara M, Yamamoto T, Tsuji O, Zasler N, Ward JD, Young HF: Posttraumatic ventriculomegaly: hydrocephalus or atrophy? A new approach for diagnosis using CSF dynamics. J Neurosurg 85:1026-35, 1996.

115. Marmarou A, Nichols J, Burgess J, Newell D, Troha J, Burnham D, Pitts L: Effects of the bradykinin antagonist Bradycor (deltibant, CP-1027) in severe traumatic brain injury: results of a mutli-center, randomized, placebo-controlled trial. American Brain Injury Consortium Study Group. J Neurotrauma 16:431-44, 1999.

116. Marshall LF, Marshall SB: Pitfalls and advances from the international tirilazad trials in moderate and severe head injury. J Neurotrauma 12:929-32, 1995.

117. Marshall LF, Marshall SB, Klauber MR, Van Berkum Clark M, Eisenberg H, Jane JA, Luerssen TG, Marmarou A, Foulkes MA: The diagnosis of head injury requires a classification based on computed axial tomography. J Neurotrauma 9 Suppl 1:S287-92, 1992.

118. Martin NA, Doberstein C, Zane C, Caron MJ, Thomas K, Becker DP: Posttraumatic cerebral arterial spasm: transcranial Doppler ultrasound, cerebral blood flow, and angiographic findings. J Neurosurg 77:575-83, 1992.

119. Martin NA, Patwardhan RV, Alexander MJ, Africk CZ, Lee JH, Shalmon E, Hovda DA, Becker DP: Characterization of cerebral hemodynamic phases following severe head trauma: hypoperfusion, hyperemia, and vasospasm. J Neurosurg 87:9-19, 1997.

120. McCarthy ML, Serpi T, Kufera JA, Demeter LA, Paidas C: Factors influencing admission among children with a traumatic brain injury. Acad Emerg Med 9:684-93, 2002.

*121. McGrath BJ, Matjasko MJ: Anesthesia and head trauma. New Horiz 3:523-33, 1995.

122. McIntosh TK, Garde E, Saatman KE, Smith DH: Central nervous system resuscitation. Emerg Med Clin North Am 15:527-50, 1997.

123. Meert KL, Long M, Kaplan J, Sarnaik AP: Alterations in immune function following head injury in children. Crit Care Med 23:822-8, 1995.

124. Meixensberger J, Baunach S, Amschler J, Dings J, Roosen K: Influence of body position on tissue-PO2, cerebral perfusion pressure and intracranial pressure in patient with acute brain injury. Neurol Res 19:249-53, 1997.

125. Menzel M, Doppenberg EM, Zauner A, Soukup J, Reinert MM, Bullock R: Increased inspired oxygen concentration as a factor in improved brain tissue oxygenation and tissue lactate levels after severe human head injury. J Neurosurg 91:1-10, 1999.

126. Metz C, Holzschuh M, Bein T, Kallenbach B, Taeger K: Jugular bulb monitoring of cerebral oxygen metabolism in severe head injury: accuracy of unilateral measurements. Acta Neurochir Suppl (Wien) 71:324-7, 1998.

127. Metz C, Holzschuh M, Bein T, Woertgen C, Frey A, Frey I, Taeger K, Brawanski A: Moderate hypothermia in patients with severe head injury: cerebral and extracerebral effects. J Neurosurg 85:533-41, 1996.

128. Michaud LJ, Duhaime AC, Batshaw ML: Traumatic brain injury in children. Pediatr Clin North Am 40:553-65, 1993.

*129. Mittl RL, Grossman RI, Hiehle JF, Hurst RW, Kauder DR, Gennarelli TA, Alburger GW: Prevalence of MR evidence of diffuse axonal injury in patients with mild head injury and normal head CT findings. Am J Neuroradiol 15:1583-9, 1994.

130. Mirski AM, Denchev ID, Schnitzer SM, Hanley FD: Comparison between hypertonic saline and mannitol in the reduction of elevated intracranial pressure in a rodent model of acute cerebral injury. J Neurosurg Anesthesiol 12:334-44, 2000.

*131. Muizelaar JP, Marmarou A, Ward JD, Kontos HA, Choi SC, Becker DP, Gruemer H, Young HF: Adverse effects of prolonged hyperventilation in patients with severe head injury: a randomized clinical trial. J Neurosurg 75:731-9, 1991.

132. Muizelaar JP, Schroder ML: Overview of monitoring of cerebral blood flow and metabolism after severe head injury. Can J Neurol Sci 21:S6-S11, 1994.

133. Murr R, Schurer L: Correlation of jugular venous oxygen saturation to spontaneous fluctuation of cerebral perfusion pressure in patient with severe head injury. Neurol Res 17:329-33, 1995.

134. Murray GD, Teasdale GM, Braakman R, Cohadon F, Dearden M, Iannotti F, Karimi A, Lapierre F, Maas A, Ohman J, Persson L, Servadei F, Stocchetti N, Trojanowski T, Unterberg A: The European Brain Injury Consortium survey of head injuries. Acta Neurochir (Wien) 141:223-36, 1999.

135. Murray GD, Teasdale GM, Schmitz H: Nimodipine in traumatic subarachnoid haemorrhage: a re-analysis of the HIT I and HIT II trials. Acta Neurochir 138:1163-7, 1996.

136. Murray JG, Gean AD, Evans SJ: Imaging of acute head injury. Semin Ultrasound CT MR 17:185-205, 1996.

137. Narayan RK, Michel ME, Ansell B, Baethmann A, Biegon A, Bracken MB, Bullock MR, Choi SC, Clifton GL, Contant CF, Coplin WM, Dietrich WD, Ghajar J, Grady SM, Grossman RG, Hall ED, Heetderks W, Hovda DA, Jallo J, Katz RL, Knoller N, Kochanek PM, Maas AI, Majde J, Marion DW, Marmarou A, Marshall LF, McIntosh TK, Miller E, Mohberg N, Muizelaar JP, Pitts LH, Quinn P, Riesenfeld G, Robertson CS, Strauss KI, Teasdale G, Temkin N, Tuma R, Wade C, Walker MD, Weinrich M, Whyte J, Wilberger J, Young AB, Yurkewicz L: Clinical trials in head injury. J Neurotrauma 19:503-57, 2002.

138. Newell DW, Weber JP, Watson R, Aaslid R, Winn HR: Effect of transient moderate hyperventilation on dynamic cerebral autoregulation after severe head injury. Neurosurgery 39:35-43, 1996.

139. Nordstrom CH, Messeter K, Sundbarg G, Schalen W, Werner M, Ryding E: Cerebral blood flow, vasoreactivity, and oxygen consumption during barbiturate therapy in severe traumatic brain lesions. J Neurosurg 68:424-31, 1988.

140. O'Callahan JG, Fink C, Pitts LH, Luce JM: Withholding and withdrawing of life support from patients with severe head injury. Crit Care Med 23:1567-75, 1995.

141. O'Mara NB, Jones PR, Anglin DL, Cox S, Nahata MC: Pharmacokinetics of phenytoin in children with acute neurotrauma. Crit Care Med 23:1418-24, 1995.

142. Ommaya AK: Head injury mechanisms and the concept of preventive management: a review and critical synthesis. J Neurotrauma 12:527-46, 1995.

143. Ommaya AK, Goldsmith W, Thibault L: Biomechanics and neuropathology of adult and paediatric head injury. Br J Neurosurg 16:220-42, 2002.

144. Ornstein E, Young WL, Fleischer LH, Ostapkovich N: Desflurane and isoflurane have similar effects on cerebral blood flow in patients with intracranial mass lesions. Anesthesiology 79:498-502, 1993.

145. O'Sullivan MG, Statham PF, Jones PA, Miller JD, Dearden NM, Piper IR, Anderson SI, Housley A, Andrews PJ, Midgley S, Corrie J, Tocher JI, Sellar R: Role of intracranial pressure monitoring in severely head-injured patients without signs of intracranial hypertension on initial computerized tomography. J Neurosurg 80:46-50, 1994.

146. Ott L, Young B, Phillips R, McClain C, Adams L, Dempsey R, Tibbs P, Ryo UY: Altered gastric emptying in the head-injured patient: relationship to feeding intolerance. J Neurosurg 74:738-42, 1991.

147. Perez-Arjona E, Dujovny M, Vinas F, Park HK, Lizarraga S, Park T, Diaz FG: CNS child abuse: epidemiology and prevention. Neurol Res 24:29-40, 2002.

148. Phillips R, Ott L, Young B, Walsh J: Nutritional support and measured energy expenditure of the child and adolescent with head injury. J Neurosurg 67:846-51, 1987.

149. Piek J: Medical complications in severe head injury. New Horiz 3:534-8, 1995.

150. Pikus HJ, Ball PA: Characteristics of cerebral gunshot injuries in the rural setting. Neurosurg Clin North Am 6:611-20, 1995.

151. Pitts LH. Neurotrauma and trauma systems. New Horiz 3:546-8, 1995.

152. Plougmann J, Astrup J, Pedersen J, Gyldensted C: Effect of stable xenon inhalation on intracranial pressure during measurement of cerebral blood flow in head injury. J Neurosurg 81:822-8, 1994.

153. Polin RS, Shaffrey ME, Phillips CD, Germanson T, Jane JA: Multivariate analysis and prediction of outcome following penetrating head injury. Neurosurg Clin North Am 6:689-99, 1995.

154. Polin RS, Shaffrey ME, Bogaev CA, Tisdale N, Germanson T, Bocchicchio B, Jane JA: Decompressive bifrontal craniectomy in the treatment of severe refractory posttraumatic cerebral edema. Neurosurgery 41:84-92, 1997.

155. Prough DS, Lang J: Therapy of patients with head injuries: key parameters for management. J Trauma 42(5 Suppl):S10-S18, 1997.

156. Rea GL, Rockswold GL: Barbiturate therapy in uncontrollable intracranial hypertension. Neurosurgery 12:401-4, 1982.

157. Report on the Traumatic Coma Data Bank. J Neurosurg 75:S1-S66, 1991.

158. Resnick DK, Marion DW, Carlier P: Outcome analysis of patients with severe head injuries and prolonged intracranial hypertension. J Tauma 42:1108-11, 1997.

159. Rimel RW, Giordani B, Barth JT, Jane JA: Moderate head injury: completing the clinical spectrum of brain trauma. Neurosurgery 11:344-51, 1982.

160. Roberts I, Schierhout G, Alderson P: Absence of evidence for the effectiveness of five interventions routinely used in the intensive care management of severe head injury: a systematic review. J Neurol Neurosurg Psychiatry 65:729-33, 1998.

161. Roberts PR: Nutrition in the head-injured patient. New Horiz 3:506-17, 1995.

162. Robertson C: Measurements of cerebral blood flow and metabolism in severe head injury using the Kety-Schmidt technique. Acta Neurochir 59:25-7, 1993.

163. Robertson C, Cormio M: Cerebral metabolic management. New Horiz 3:410-422, 1995.

*164. Robertson CS: Management of cerebral perfusion pressure after traumatic brain injury. Anesthesiology 95:1513-7, 2001.

165. Robertson CS, Gopinath SP, Goodman JC, Contant CF, Valadka AB, Narayan RK: SjvO2 monitoring in head-injured patients. J Neurotrauma 12:891-6, 1995.

166. Robertson CS, Gopinath SP, Chance B: A new application for near-infrared spectroscopy: detection of delayed intracranial hematomas after head injury. J Neurotrauma 12:591-600, 1995.

167. Robertson CS, Valadka AB, Hannay HJ, Contant CF, Gopinath SP, Cormio M, Uzura M, Grossman RG: Prevention of secondary ischemic insults after severe head injury. Crit Care Med 27:2086-95, 1999.

168. Rockswold GL, Leonard PR, Nagib MG: Analysis of management in thirty-three closed head injury patients who "talked and deteriorated." Neurosurgery 21:51-5, 1987.

169. Romner B, Bellner J, Kongstad P, Sjoholm H: Elevated transcranial Doppler flow velocities after severe head injury: cerebral vasospasm or hyperemia? J Neurosurg 85:90-7, 1996.

*170. Rosner MJ, Rosner SD, Johnson AH: Cerebral perfusion pressure: management protocol and clinical results. J Neurosurg 83:949-62, 1995.

171. Rosomoff HL, Kochanek PM, Clark R, DeKosky ST, Ebmeyer U, Grenvik AN, Marion DW, Obrist W, Palmer AM, Safer P, White RJ: Resuscitation from severe brain trauma. Crit Care Med 24(2 Suppl):S48-S56, 1996.

172. Rothoerl RD, Woertgen C, Holzschuh M, Metz C, Brawanski A: S-100 serum levels after minor and major head injury. J Trauma 45:765-7, 1998.

173. Sakas DE, Bullock MR, Patterson J, Hadley D, Wyper DJ, Teasdale GM: Focal cerebral hyperemia after focal head injury in humans: a benign phenomenon? J Neurosurg 83:277-84, 1995.

174. Sakas DE, Bullock MR, Teasdale GM: One-year outcome following craniotomy for traumatic hematoma in patients with fixed dilated pupils. J Neurosurg 82:961-5, 1995.

175. Scalea TM, Maltz S, Yelon J, Trooskin SZ, Duncan AO, Sclafani SA: Resuscitation of multiple trauma and head injury: role of crystalloid fluids and inotropes. Crit Care Med 22:1610-15, 1994.

176. Schmoker JD, Shackford SR, Zhuang J: The effect of lesion volume on cerebral vasomotor tone after focal brain injury and shock. J Neurotrauma 13:67-78, 1996.

177. Schneider GH, Bardt T, Lanksch WR, Unterberg A: Decompressive craniectomy following traumatic brain injury: ICP, CPP and neurological outcome. Acta Neurochir Suppl 81:77-9, 2002.

178. Schneider GH, von Helden AV, Franke R, Lanksch WR, Unterberg A: Influence of body position on jugular venous oxygen saturation, intracranial pressure and cerebral perfusion pressure. Acta Neurochir (Wien) 59:107-12, 1993.

179. Schneider GH, Helden AV, Lanksch WR, Unterberg A: Continuous monitoring of jugular bulb oxygen saturation in comatose patients-therapeutic implications. Acta Neurochir 134:71-5, 1995.

180. Schroder ML, Muizelaar JP, Bullock MR, Salvant JB, Povlishock JT: Focal ischemia due to traumatic contusions documented by stable xenon-CT and ultrastructural studies. J Neurosurg 82:966-71, 1995.

181. Schroder ML, Muizelaar JP, Kuta AJ, Choi SC: Thresholds for cerebral ischemia after severe head injury: relationship with late CT findings and outcome. J Neurotrauma 13:17-23, 1996.

182. Schrot RJ, Muizelaar JP: Mannitol in acute traumatic brain injury. Lancet 359:1633-4, 2002.

183. Servadei F: Prognostic factors in severely head injured adult patients with acute subdural haematoma's. Acta Neurochir 139:279-85, 1997.

184. Servadei F: Prognostic factors in severely head injured adult patients with epidural hematoma's. Acta Neurochir 139:273-8, 1997.

185. Shapira Y, Lam AM, Paez A, Artru AA, Laohaprasit V, Donato T: The influence of acute and chronic alcohol treatment on brain edema, cerebral infarct volume and neurologial outcome following experimental head trauma in rats. J Neurosurg Anesthesiol 9:118-27, 1997.

186. Sharples PM, Matthews DSF, Eyre JA: Cerebral blood flow and metabolism in children with severe head injuries. Part 2: cerebrovascular resistance and its determinants. J Neurol Neurosurg Psychiatry 58:153-9, 1995

187. Sheinberg M, Kanter MJ, Robertson CS, Contant CF, Narayan RK, Grossman RG: Continuous monitoring of jugular venous oxygen saturation in head-injured patients. J Neurosurg 76:212-17, 1992.

188. Shiozaki T, Sugimoto H, Taneda M, Yoshida H, Iwai A, Yoshioka T, Sugimoto T: Effect of mild hypothermia on uncontrollable intracranial hypertension after severe head injury. J Neurosurg 79:363-8, 1993.

189. Shigemori M, Moriyama T, Harada K, Kikuchi N, Tokutomi T, Kuramoto S: Intracranial haemodynamics in diffuse and focal brain injuries: evaluation with transcranial Doppler (TCD) ultrasound. Acta Neurochir 107:5-10, 1990.

190. Sioutos PJ, Orozco JA, Carter LP, Weinand ME, Hamilton AJ, Williams FC: Continuous regional cerebral cortical blood flow monitoring in head-injured patients. Neurosurgery 36:943-9, 1995.

191. Skippen P, Seear M, Poskitt K, Kestle J, Cochrane D, Annich G, Handel J: Effect of hyperventilation on regional cerebral blood flow in head-injured children. Crit Care Med 25:1402-9, 1997.

192. Sloan TB: Electrophysiologic monitoring in head injury. New Horiz 3:431-8, 1995.

193. Smith DH, Meaney DF, Lenkinski RE, Alsop DC, Grossman R, Kimura H, McIntosh TK, Gennarelli TA: New magnetic resonance imaging techniques for the evaluation of traumatic brain injury. J Neurotrauma 12:573-7, 1995.

194. Soloniuk D, Pitts LH, Lovely M, Bartkowski HL: Traumatic intracerebral hematomas: timing of appearance and indications for operative removal. J Trauma 26:787-94, 1986.

195. Sosin DM, Sniezek JE, Waxweller RJ: Trends in death associated with traumatic brain injury 1979 through 1992. JAMA 273:1778-80, 1995.

196. Souter MJ, Andrews PJ, Piper IR, Miller JD: Effects of alfentanil on cerebral haemodyanmics in an experimental model of traumatic brain injury. Br J Anaesth 79:97-102, 1997.

197. Steiger HJ, Ciessinna E, Seiler RW: Identification of posttraumatic ischemia and hyperperfusion by determination of the effect of induced arterial hypertension on carbon dioxide reactivity. Stroke 27:2048-51, 1996.

198. Stein SC, Chen XH, Sinson GP, Smith DH: Intravascular coagulation: a major secondary insult in nonfatal traumatic brain injury. J Neurosurg 97:1373-7, 2002.

199. Stein SC, Young GS, Talucci RC, Greenbaum BH, Ross SE: Delayed brain injury after head trauma: significance of coagulopathy. Neurosurgery 30:160-5, 1992.

200. Steiner LA, Czosnyka M, Piechnik SK, Smielewski P, Chatfield D, Menon DK, Pickard JD: Continuous monitoring of cerebrovascular pressure reactivity allows determination of optimal cerebral perfusion pressure in patients with traumatic brain injury. Crit Care Med 30:733-8, 2002.

201. Stringer WA, Hasso AN, Thompson JR, Hinshaw DB, Jordon KG: Hyperventilation-induced cerebral ischemia in patients with acute brain lesions: demonstration by xenon-enhanced CT. Am J Neuroradiol 14:475-84, 1993.

202. Talmor D, Roytblat L, Shapira Y, Artru AA: Are vasopressors beneficial after cranial trauma?. Anesth Analg 88:1423-4, 1999.

203. Taneda M, Kataoka K, Akai F, Asai T, Sakata I: Traumatic subarachnoid hemorrhage as a predictable indicator of delayed ischemic symptoms. J Neurosurg 84:762-8, 1997.

204. Teasdale GM, Jennett B: Assessment of coma and impaired consciousness: a practical scale. Lancet 2:81-4, 1974.

205. Thomas JE, Rosenwasser RH, Armonda RA, Harrop J, Mitchell W, Galaria I: Safety of intrathecal sodium nitroprusside for the treatment and prevention of refractory cerebral vasospasm and ischemia in humans. Stroke 30:1409-16, 1999.

206. Thomas SH, Orf J, Wedel SK, Conn AK: Hyperventilation in traumatic brain injury patients: inconsistency between consensus guidelines and clinical practice. J Trauma 52:47-52, 2002.

207. Tommasino C, Grana C, Lucignani G, Torri G, Fazio F: Regional cerebral metabolism of glucose in comatose and vegetative state patients. J Neurosurg Anesthesiol 7:109-16, 1995.

208. Ungerstedt JS, Grenander A, Bredbacka S, Blomback M: Clotting onset time may be a predictor of outcome in human brain injury: a pilot study. J Neurosurg Anesthesiol 15:13-8, 2003.

209. Unterberg A, Schneider GH, Gottschalk J, Lanksch WR: Development of traumatic brain edema in old versus young rats. Acta Neurochir Suppl 60:431-3, 1994.

210. Valadka AB, Gopinath SP, Contant CF, Uzura M, Robertson CS: Relationship of brain tissue PO2 to outcome after severe head injury. Crit Care Med 26:1576-81, 1998.

211. van Santbrink H, Maas AI, Avezaat CJ: Continuous monitoring of partial pressure of brain tissue oxygen in patients with severe head injury. Neurosurgery 38:21-31, 1996.

212. Vavilala MS, Lam AM: Perioperative considerations in pediatric traumatic brain injury. Int Anesthesiol Clin 40:69-87, 2002.

213. Vincent FM, Zimmerman JE, Van Haven J: Neuroleptic malignant syndrome complicating closed head injury. Neurosurgery 18:190-3, 1986.

214. Vollmer DG, Torner JC, Jane JA, Sadovnic B, Charlebois D, Eisenberg HM: Age and outcome following traumatic coma: why do older patients fare worse? J Neurosurg 75:S37-S47, 1991.

215. Wald SL: Advances in the early management of patients with head injury. Surg Clin North Am 75:225-42, 1995.

*216. Ward JD, Becker DP, Miller JD, Choi SC, Marmarou A, Wood C, Newlon PG, Keenan R: Failure of prophylactic barbiturate coma in the treatment of severe head injury. J Neurosurg 62:383-8, 1985.

217. Ward JD: Pediatric issues in head trauma. New Horiz 3:539-45, 1995.

218. Wellwood J, Alcantara A, Michael DB: Neurotrauma: the role of CT angiogram. Neurol Res 24:S13-6, 2002.

219. White H, Baker A: Continuous jugular venous oximetry in the neurointensive care unit-a brief review. Can J Anaesth 49:623-9, 2002.

220. Wilberger JE, Cantella D: High-dose barbiturates for intracranial pressure control. New Horiz 3:469-73, 1995.

221. Wilberger JE Jr, Harris M, Diamond DL: Acute subdural hematoma: morbidity, mortality, and operative timing. J Neurosurg 74:212-18, 1991.

222. Winchell RJ, Hoyt DB: Endotracheal intubation in the field improves survival in patients with severe head injury. Trauma Research and Education Foundation of San Diego. Arch Surg 132:592-7, 1997.

223. Yanagawa T, Bunn F, Roberts I, Wentz R, Pierro A: Nutritional support for head-injured patients. Cochrane Database Syst Rev CD001530, 2002.

224. Yoshihara M, Bandoh K, Marmarou A: Cerebrovascular carbon dioxide reactivity assessed by intracranial pressure dynamics in severely head injured patients. J Neurosurg 82:386-93, 1995.

225. Young JS, Meredith JW: Does oxygen delivery-directed resuscitation worsen outcome of head injured patients with multisystem injuries? Am Surg 61:419-23, 1995.

226. Yundt KD, Diringer MN: The use of hyperventilation and its impact on cerebral ischemia in the treatment of traumatic brain injury. Crit Care Clin 13:163-84, 1997.

227. Zauner A, Clausen T, Alves OL, Rice A, Levasseur J, Young HF, Bullock R: Cerebral metabolism after fluid-percussion injury and hypoxia in a feline model. J Neurosurg 97:643-9, 2002.

228. Zurynski YA, Dorsch NW, Fearnside MR: Incidence and effects of increased cerebral blood flow velocity after severe head injury: a transcranial Doppler ultrasound study II. Effect of vasospasm and hyperemia on outcome. J Neurol Sci 134:41-6, 1995.

229. Zurynski YA, Dorsch NW, Pearson I: Incidence and effects of increased cerebral blood flow velocity after severe head injury: a transcranial Doppler ultrasound study I. Prediction of post-traumatic vasospasm and hyperemia. J Neurol Sci 134:33-40, 1995.

II. Cardiopulmonary Effects

1. Borel C, Hanley D, Diringer MN, Rogers MC: Intensive management of severe head injury. Chest 98:180-9, 1991.

2. Bratton SL, Davis RL: Acute lung injury in isolated traumatic brain injury. Neurosurgery 40:707-12, 1997.

3. Braun SR, Levin AB, Clark KL: Role of corticosteroids in the development of pneumonia in mechanically ventilated head-trauma victims. Crit Care Med 14:198-201, 1986.

4. Chen HI: Hemodynamic mechanisms of neurogenic pulmonary edema. Biol Signals 4:186-92, 1995.

*5. Chesnut RM: Medical management of severe head injury: present and future. New Horiz 3:581-93, 1995.

6. Clifton Gl, Robertson CS, Grossman RG: Cardiovascular and metabolic response to severe head injury. Neurosurg Rev 12(Suppl 1):465-73, 1989.

7. Collins KA, Davis GJ: A retrospective and prospective study of cerebral tissue pulmonary embolism in severe head trauma. J Forensic Sci 39:624-8, 1994.

8. Cooper KR, Boswell PA, Choi SC: Safe use of PEEP in patients with severe head injury. J Neurosurg 63:552-5, 1985.

9. Crone KR, Lee KS, Kelly DL: Correlation of admission fibrin degradation products with outcome and respiratory failure in patients with severe head injury. Neurosurgery 21:532-6, 1987.

10. Cruickshank JM, Neil-Dwyer G, Hayes Y, Degaute JP, Kuurne T, Kytta J, Carruthers ME, Patel S: Stress/catecholamine-induced cardiac necrosis. Reduction by beta 1-selective blockade. Postgrad Med 83:140-7, 1988.

11. Dettbarn C, Davidson L: Pulmonary complications in the patient with acute head injury: neurogenic pulmonary edema. Heart Lung 18:583-9, 1989.

12. Ersson U, Carlson H, Mellstrom A, Ponten U, Hedstrand U, Jakobsson S: Observation on intracranial dynamics during respiratory physiotherapy in unconscious neurosurgical patients. Acta Anaesthesiol Scand 34:99-103, 1990.

13. Goldstein B, Kempski MH, DeKing D, Cox C, DeLong DJ, Kelly MM, Woolf PD: Autonomic control of heart rate after brain injury in children. Crit Care Med 24:234-40, 1996.

14. Hackenberry LE, Miner ME, Rea GL: Biochemical evidence of myocardial injury after severe head trauma. Crit Care Med 10:641-4, 1982.

15. Hersch C: Electrocardiographic changes in head injuries. Circulation 23:853-60, 1961.

16. Hsieh AH, Bishop MJ, Kubilis PS, Newell DW, Pierson DJ: Pneumonia following closed head injury. Am Rev Respir Dis 146:290-4, 1992.

+17. Kaufman HH, Timberlake G, Voelker J, Pait TG: Medical complications of head injury. Med Clin North Am 77:43-60, 1993.

18. King ML, Lichtman SW, Seliger G, Ehert FA, Steinberg JS: Heart-rate variability in chronic traumatic brain injury. Brain Inj 11:445-53, 1997.

19. Kroppenstedt SN, Sakowitz OW, Thomale UW, Unterberg AW, Stover JF: Influence of norepinephrine and dopamine on cortical perfusion, EEG activity, extracellular glutamate, and brain edema in rats after controlled cortical impact injury. J Neurotrauma 19:1421-32, 2002.

20. Kroppenstedt SN, Sakowitz OW, Thomale UW, Unterberg AW, Stover JF: Norepinephrine is superior to dopamine in increasing cortical perfusion following controlled cortical impact injury in rats. Acta Neurochir Suppl 81:225-7, 2002.

21. MacKersie RC, Christensen JM, Pitts LH, Lewis FR: Pulmonary extravascular fluid accumulation following intracranial injury. J Trauma 23:968-75, 1983.

22. Malik AB: Mechanisms of neurogenic pulmonary edema. Circ Res 57:1-18, 1985.

23. McLeod AA, Neil-Dwyer G, Meyer CHA, Richardson PL, Cruickshank J, Bartlett J: Cardiac sequelae of acute head injury. Br Heart J 47:221-6, 1982.

*24. Piek J: Medical complications in severe head injury. New Horiz 3:534-9, 1995.

25. Piek J, Chestnut RM, Marshall LF, van Berkum-Clark M, Klauber MR, Blunt BA, Eisenberg HM, Jane JA, Marmarou A, Foulkes MA: Extracranial complications of severe head injury. J Neurosurg 77:901-7, 1992.

26. Popp AJ, Gottlieb ME, Paloski WH: Cardiopulmonary hemodynamics in patients with serious head injury. J Surg Res 32:416-21, 1982.

27. Popp AJ, Shah DM, Berman RA: Delayed pulmonary dysfunction in head-injured patients. J Neurosurg 57:784-90, 1982.

28. Schoning M, Scheel P, Holzer M, Fretschner R, Will BE: Can a critical lower threshold of cerebral perfusion be determined? A pilot observational study. Neurology 58:1860-1, 2002.

29. Schumacker PT, Rhodes GR, Newell JC, Dutton RE, Shah DM, Scovill WA, Powers SR: Ventilation-perfusion imbalance after head trauma. Am Rev Respir Dis 119:33-43, 1979.

30. Slack RS, Shucart W: Respiratory dysfunction associated with traumatic injury to the central nervous system. Clin Chest Med 15:739-49, 1994.

31. Sutherland GR, Amacher AL, Sibbald WJ, Driedger AL: Heart injury in head-injured adolescents. Childs Nerv Syst 1:219-22, 1985.

32. Tonnesen AS: Hemodynamic management of brain-injured patients. New Horiz 3:499-505, 1995.

III. Pathophysiology and Genetics

1. Adelson PD, Jenkins LW, Hamilton RL, Robichaud P, Tran MP, Kochanek PM: Histopathologic response of the immature rat to diffuse traumatic brain injury. J Neurotrauma 18: 967-976, 2001.

2. Albensi BC, Knoblach SM, Chew BG, O'Reilly MP, Faden AI, Pekar JJ: Diffusion and high resolution MRI of traumatic brain injury in rats: time course and correlation with histology. Exp Neurol 162:61-72, 2000.

3. Arvin B, Neville LF, Barone FC, Feuerstein GZ: The role of inflammation and cytokines in brain injury. Neurosci Biobehav Rev 20:445-52, 1996.

4. Assaf Y, Holokovsky A, Berman E, Shapira Y, Shohami E, Cohen Y: Diffusion and perfusion magnetic resonance imaging following closed head injury in rats. J Neurotrauma 16:1165-76, 1999.

5. Bareyre FM, Saatman KE, Helfaer MA, Sinson G, Weisser JD, Brown AL, McIntosh TK: Alterations in ionized and total blood magnesium after experimental traumatic brain injury: relationship to neurobehavioral outcome and neuroprotective efficacy of magnesium chloride. J Neurochem 73:271-80, 1999.

6. Barie PS, Ghajar JB, Firlik AD, Chang VA, Hariri RJ: Contribution of increased cerebral blood volume to posttraumatic intracranial hypertension. J Trauma 35:88-95, 1993.

7. Bayir H, Kochanek PM, Liu SX, Arroyo A, Osipov A, Jiang J, Wisniewski S, Adelson PD, Graham SH, Kagan VE: Increased S-nitrosothiols and S-nitrosoalbumin in cerebrospinal fluid after severe traumatic brain injury in infants and children: indirect association with intracranial pressure. J Cereb Blood Flow Metab 23:51-61, 2002.

8. Berger RP, Pierce MC, Wisniewski SR, Adelson PD, Clark RS, Ruppel RA, Kochanek PM: Neuron-specific enolase and S100B in cerebrospinal fluid after severe traumatic brain injury in infants and children. Pediatrics 109:E31, 2002.

9. Berger RP, Pierce MC, Wisniewski SR, Adelson PD, Kochanek PM: Serum S100B Concentrations Are Increased after Closed Head Injury in Children: A Preliminary Study. J Neurotrauma 19:1405-9, 2002.

10. Bergsneider M, Hovda DA, Shalmon E, Kelly DE, Vespa PM, Martin NA, Phelps ME, McArthur DL, Caron MJ, Kraus JE, Becker DP: Cerebral hyperglycolysis following severe traumatic brain injury in humans: a positron emission tomography study. J Neurosurg 86:241-51, 1997.

11. Bethea JR, Nagashima H, Acosta MC, Briceno C, Gomez F, Marcillo AE, Loor K, Green J, Dietrich WD: Systemically administered interleukin-10 reduces tumor necrosis factor-alpha production and significantly improves functional recovery following traumatic spinal cord injury in rats. Neurotrauma 16:851-63, 1999.

12. Bouma GJ, Muizelaar JP, Choi SC, Newlon PG, Young HF: Cerebral circulation and metabolism after severe traumatic brain injury: the elusive role of ischemia. J Neurosurg 75:685-93, 1991.

13. Bullock R: Strategies for neuroprotection with glutamate antagonists. Extrapolating from evidence taken from the first stroke and head injuries studies. Ann NY Acad Sci 765:272-8, 1975.

14. Bullock R, Statham P, Patterson J, Wyper D, Hadley D, Teasdale E: The time course of vasogenic oedema after focal human head injury(evidence from SPECT mapping of blood brain barrier defects. Acta Neurochir 51(Suppl):286-8, 1990.

15. Bullock R, Zauner A, Woodward JJ, Myseros J, Choi SC, Ward JD, Marmarou A, Young HF: Factors affecting excitatory amino acid release following severe human head injury. J Neurosurg 89:507-18, 1998.

16. Cuevas P, Gimenez-Gallego G: Role of fibroblast growth factors in neural trauma. Neurol Res 19:254-6, 1997.

17. Cole DJ, McKay LD, Drummond JC, Patel PM, Cross LM: Subarachnoid molecular hemoglobin after subarachnoid hemorrhage in rats: effect on the area of hypoperfusion. Neurosurg Anesthesiol 10:153-9, 1998.

18. Compton JS, Lee T, Jones NR, Waddell G, Teddy PJ: A double blind placebo controlled trial of the calcium entry blocking drug, nicardipine, in the treatment of vasospasm following severe head injury. Br J Neurosurg 4:9-15, 1990.

19. Conti AC, Raghupathi R, Trojanowski JQ, McIntosh TK: Experimental brain injury induces regionally distinct apoptosis during the acute and delayed post-traumatic period. J Neurosci 18:5663-72, 1998.

20. Darby JM, Nemoto EM, Yonas H, Yao L, Melick JA, Boston JR: Local cerebral blood flow measured by xenon-enhanced CT during cryogenic brain edema and intracranial hypertension in monkeys. J Cereb Blood Flow Metab 13:763-72, 1993.

21. DeSalles AAF, Muizelaar JP, Young HF: Hyperglycemia, cerebrospinal fluid lactic acidosis, and cerebral blood flow in severely head-injured patients. Neurosurgery 21:45-50, 1987.

22. Deutschman CS, Konstantinides FN, Raup S, Thienprasit P, Cerra FB: Physiological and metabolic response to isolated closed-head injury. J Neurosurg 64:89-98, 1986.

23. DeWitt DS, Jenkins LW, Prough DS: Enhanced vulnerability to secondary ischemic insults after experimental traumatic brain injury. New Horiz 3:376-83, 1995.

24. DeWitt DS, Smith TG, Deyo DJ, Miller KR, Uchida T, Prough DS: L-arginine and superoxide dismutase prevent or reverse cerebral hypoperfusion after fluid-percussion traumatic brain injury. J Neurotrauma 14:223-33, 1997.

25. DeWitt DS, Prough DS, Taylor CL, Whitley JM: Reduced cerebral blood flow, oxygen delivery, and electroencephalographic activity after traumatic brain injury and mild hemorrhage in cats. J Neurosurg 76:812-21, 1992.

26. Dhillon HS, Dose JM, Scheff SW, Prasas MR: Time course of changes in lactate and free fatty acids after experimental brain injury and relationship to morphologic damage. Exp Neurol 146:240-9, 1997.

27. Dixon CE, Flinn P, Bao J, Venya R, Hayes RL: Nerve growth factor attenuates cholingergic deficits following traumatic brain injury in rats. Exp Neurol 146:479-90, 1997.

28. Dixon CE, Kochanek PM, Yan HQ, Schiding JK, Griffith RG, Baum E, Marion DW, DeKosky ST: One-year study of spatial memory performance, brain morphology, and cholinergic markers after moderate controlled cortical impact in rats. J Neurotrauma 16:109-22, 1999.

29. Faden AI: Experimental neurobiology of central nervous system trauma. Clinical Reviews in Neurobiology 7:175-86, 1993.

30. Fan L, Yakovlev AG, Faden AI: Site-specific cleavage of 28S rRNA as a marker of traumatic brain injury. J Neurotrauma 16:357-64, 1999.

31. Gennarelli TA: Mechanisms of brain injury. J Emerg Med 11:5-11, 1993.

32. Golding EM, Robertson CS, Bryan Rm Jr: The consequences of traumatic brain injury on cerebral blood flow and autoregulation: a review. Clin Exp Hypertens 21:299-332, 1999.

33. Goss JR, Taffe KM, Kochanek PM, DeKosky ST: The antioxidant enzymes glutathione peroxidase and catalase increase following traumatic brain injury in the rat. Exp Neurol 146:291-4, 1997.

34. Grady MS, Cody RF Jr, Maris DO, McCall TD, Seckin H, Sharar SR, Winn HR: P-selectin blockade following fluid-percussion injury: behavioral and immunochemical sequelae. J Neurotrauma 16:13-25, 1999.

35. Graham DI, Gentleman SM, Lynch A, Roberts GW: Distribution of amyloid protein in the brain following severe head injury. Neuropathol Appl Neurobiol 21:27-34, 1995.

36. Gurevich B, Artru AA, Lam AM, Mueller AL, Merkind V, Talmor D, Katchko L, Shapira Y: Neuroprotective effects of NPS 846, a novel N-methyl-D-aspartate receptor antagonist, after closed head trauma in rats. J Neurosurg 88:1066-74, 1998.

37. Hill-Felberg SJ, McIntosh TK, Oliver DL, Raghupathi R, Barbarese E: Concurrent loss and proliferation of astrocytes following lateral fluid percussion brain injury in the adult rat. J Neurosci Res 57:271-9, 1999.

38. Hovda DA, Lee SM, Smith ML, Von Stuck S, Bergsneider M, Kelly D, Shalmon E, Martin N, Caron M, Mazziotta J: The neurochemical and metabolic cascade following brain injury: moving from animal models to man. J Neurotrauma 12:903-6, 1995.

39. Huang PP, Esquenazi S, Le Roux PD: Cerebral cortical neuron apoptosis after mild excitotoxic injury in vitro: different roles of mesencephalic and cortical astrocytes. Neurosurgery 45:1413-22, 1999.

40. Hulsebosch CE, DeWitt DS, Jenkins LW, Prough DS: Traumatic brain injury in rats results in increased expression of Gap-43 that correlates with behavioral recovery. Neurosci Lett 255:83-6, 1998.

41. Iadecola C: Bright and dark sides of nitric oxide in ischemic brain injury. Trends Neurosci 20:132-9, 1997.

42. Ingebrigtsen T, Romner B: Biochemical serum markers of traumatic brain injury. J Trauma 52:798-808, 2002.

43. Jaggi JL, Obrist WD, Gennarelli TA, Langfitt TW: Relationship of early cerebral blood flow and metabolism to outcome in acute head injury. J Neurosurg 72:176-82, 1990.

44. Kaya SS, Mahmood A, Li Y, Yavuz E, Chopp M: Expression of cell cycle proteins (cyclin D1 and cdk4) after controlled cortical impact in rat brain. J Neurotrauma 16:1187-96, 1999.

45. Ke C, Poon WS, Ng HK, Lai FM, Tang NL, Pang JC: Impact of experimental acute hyponatremia on severe traumatic brain injury in rats: influences on injuries, permeability of blood-brain barrier, ultrastructural features, and aquaporin-4 expression. Exp Neurol 178:194-206, 2002.

46. Kelly DF: Alcohol and head injury: an issue revisited. J Neurotrauma 12:883-90, 1995.

47. Khaldi A, Chiueh CC, Bullock MR, Woodward JJ: The significance of nitric oxide production in the brain after injury. Ann N Y Acad Sci 962:53-9, 2002.

48. King AI, Ruan JS, Zhou C, Hardy WN, Khalil TB: Recent advances in biomechanics of brain injury research: a review. J Neurotrauma 12:651-8, 1995.

49. Knoblach SM, Faden AI: Interleukin-10 improves outcome and alters proinflammatory cytokine expression after experimental traumatic brain injury. Exp Neurol 153:143-51, 1998.

50. Knoblach SM, Fan L, Faden AI: Early neuronal expression of tumor necrosis factor-alpha after experimental brain injury contributes to neurological impairment. J Neuroimmunol 95:115-25, 1999.

51. Krishnappa IK, Contant CF, Robertson CS: Regional changes in cerebral extracellular glucose and lactate concentrations following severe cortical impact injury and secondary ischemia in rats. J Neurotrauma 16:213-24, 1999.

52. Landis DMD: The early reactions of non-neuronal cells to brain injury. Annu Rev Neurosci 17:133-51, 1994.

53. Lankhorst AJ, Duis SE, ter Laak MP, Joosten EA, Hamers FP, Gispen WH: Functional recovery after central infusion of alpha-melanocyte-stimulating hormone in rats with spinal cord contusion injury. J Neurotrauma 16:323-31, 1999.

54.